Zip Codes are cis acting post-transcriptional regulatory motifs, often found e.g. in 3'UTRs, that direct the localization of mRNAs.
An example is the Translational Control Element (TCE) found in the 3'UTR of nanos, which establishes a posterior-anterior axis during development of fruitfly oocytes (proto-eggs). This localization of the transcript is achieved via complementary, redundant mechanisms of selective degradation and transport.
- Singer &: RNA zipcodes for cytoplasmic addresses. Curr. Biol. 1993;3:719-21.
- Crucs et al.: Overlapping but distinct RNA elements control repression and activation of nanos translation. Mol. Cell 2000;5:457-67.
- Bashirullah et al.: RNA localization in development. Annu. Rev. Biochem. 1998;67:335-94.
-- Ian Holmes - 03 Apr 2005