Nucleic Acid Engineering

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Nucleic acid engineering

Mindblowingly cool design of riboswitches, nucleic acid logic circuits, etc.

This page mostly focuses on deliberate attempts to imitate electronic circuit design, and is obviously waaaay incomplete; I haven't even scratched the surface, really. It's strongest for logic gates and suchlike, and very weak on applications and on the chemical diversity of RNA. I haven't even gone near DNA nanotech. (go start a page!)

Literature

...currently a very incomplete list... please add/update!

Logic gates

Energy

I/O

  • Stojanovic & Kolpashchikov: Modular aptameric sensors. J. Am. Chem. Soc. 2004;126:9266-70.
    • noncovalent attachment to fluorophore

Need more on aptamers here..

Ethics

Design principles, reviews

Applications

Cancer therapy

Gene therapy

need more up-to-date stuff here... this is a huge field

Design tools

Nupack

http://www.nupack.org/

Vienna

http://www.tbi.univie.ac.at/~ivo/RNA/

Sribo

http://sfold.wadsworth.org/sribo.pl

RNA-SSD

http://www.rnasoft.ca

Sequence databases

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