Zip Codes

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Zip Codes are cis acting post-transcriptional regulatory motifs, often found e.g. in 3'UTRs, that direct the localization of mRNAs.

An example is the Translational Control Element (TCE) found in the 3'UTR of nanos, which establishes a posterior-anterior axis during development of fruitfly oocytes (proto-eggs). This localization of the transcript is achieved via complementary, redundant mechanisms of selective degradation and transport.

-- Ian Holmes - 03 Apr 2005