Ribo Switches

Riboswitches

Discovery and analysis

• Mandal et al.: Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria. Cell 2003;113:577-86.
• Nahvi et al.: Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes. Nucleic Acids Res. 2004;32:143-50.
• Suess et al.: A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo. Nucleic Acids Res. 2004;32:1610-4.
• Serganov et al.: Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem. Biol. 2004;11:1729-41.
• Tucker & Breaker: Riboswitches as versatile gene control elements. Curr. Opin. Struct. Biol. 2005;15:342-8.

Algorithms for detection

• Bengert & Dandekar: Riboswitch finder--a tool for identification of riboswitch RNAs. Nucleic Acids Res. 2004;32:W154-9.
• Abreu-Goodger & Merino: RibEx: a web server for locating riboswitches and other conserved bacterial regulatory elements. Nucleic Acids Res. 2005;33:W690-2.