Human Metapneumovirus

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Table of Contents

• Human Metapneumovirus
• Taxonomy
• Genomic Data
• Summary
• Genes Encoded
• Genome Browser
• Morphology
• Epidemiology
• hMPV related resources and publications

Taxonomy

Order Mononegavirales [wikipedia][NCBI taxonomy][ICTVdb]
Family Paramyxoviridae [wikipedia][NCBI taxonomy][ICTVdb]
Subfamily Pneumovirinae [NCBI taxonomy][ICTVdb]
Genus Metapneumovirus [wikipedia][NCBI taxonomy][ICTVdb]
Species Human Metapneumovirus [wikipedia][NCBI Taxonomy]

Genomic Data

Summary

The genomic organisation of hMPV is analogous to RSV, however hMPV lacks the non-structural genes, NS1 and NS2, and the hMPV antisense RNA genome contains eight open reading frames in slightly different gene order than RSV (viz. 3’-N-P-M-F-M2-SH-G-L-5’). hMPV is genetically similar to the avian pneumoviruses A, B and in particular type C. Phylogenetic analysis of hMPV has demonstrated the existence of two main genetic lineages termed subtype A and B containing within them the subgroups A1/A2 and B1/B2 respectively.
[source]

Genes Encoded

Gene Name	Location	Length	Product(s)
N	55-1239	1184	Nucleoprotein
P	1263-2147	884	Phosphoprotein
M	2180-2944	764	Matrix Protein
F	3067-4686	1619	Fusion Glycoprotein Precursor
M2	4724-5287	563	Matrix Protein M2-1
M2	5235-5450	215	Matrix Protein M2-2
SH	5481-6020	539	Small Hydrophobic Protein
G	6232-6891	659	Attachment Glycoprotein G
L	7133-13150	6017	RNA Dependent RNA Polymerase
[source]

JBrowse: hMPV Genome

Morphology

Paramyxoviruses encode negative-sense, single-stranded, monopartite RNA. They are enveloped and contain a helical nucleocapsid. They appear pleomorphic or spherical in electron micrographs.
[source]

Human metapneumovirus accounts for approximately 10% of respiratory tract infections that are not related to previously known etiologic agents. The virus seems to be distributed worldwide and to have a seasonal distribution with its incidence comparable to that for the influenza viruses during winter. Serologic studies have shown that by the age of five, virtually all children have been exposed to the virus and reinfections appear to be common. Human metapneumovirus may cause mild respiratory tract infection. However, small children, elderly and immunocompromised individuals are at risk of severe disease and hospitalization.
[source]

General Information

• Wikipedia: hMPV
• emedicine: Human Metapneumovirus
• High Prevalence of Human Metapnreumovirus Infection in Young Children

Taxonomy

• Order Mononegavirales
• Family Paramyxoviridae
• Subfamily Pneumovirinae
• Genus Metapneumovirus

Genomic Data

• Data from the National Center for Biotechnology
• Complete Genome

Epidemiology

• The Emergence of Human Metapneumovirus: HMPV Detection & Epidemiology

Pathology

• Pathology of Human Metapneumovirus