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Table of Contents
Order Mononegavirales [wikipedia][NCBI taxonomy][ICTVdb]
Family Paramyxoviridae [wikipedia][NCBI taxonomy][ICTVdb]
Subfamily Pneumovirinae [NCBI taxonomy][ICTVdb]
Genus Metapneumovirus [wikipedia][NCBI taxonomy][ICTVdb]
Species Human Metapneumovirus [wikipedia][NCBI Taxonomy]
The genomic organisation of hMPV is analogous to RSV, however hMPV lacks the non-structural genes, NS1 and NS2, and the hMPV antisense RNA genome contains eight open reading frames in slightly different gene order than RSV (viz. 3’-N-P-M-F-M2-SH-G-L-5’). hMPV is genetically similar to the avian pneumoviruses A, B and in particular type C. Phylogenetic analysis of hMPV has demonstrated the existence of two main genetic lineages termed subtype A and B containing within them the subgroups A1/A2 and B1/B2 respectively.
||Fusion Glycoprotein Precursor
||Matrix Protein M2-1
||Matrix Protein M2-2
||Small Hydrophobic Protein
||Attachment Glycoprotein G
||RNA Dependent RNA Polymerase
Paramyxoviruses encode negative-sense, single-stranded, monopartite RNA. They are enveloped and contain a helical nucleocapsid. They appear pleomorphic or spherical in electron micrographs.
Human metapneumovirus accounts for approximately 10% of respiratory tract infections that are not related to previously known etiologic agents. The virus seems to be distributed worldwide and to have a seasonal distribution with its incidence comparable to that for the influenza viruses during winter. Serologic studies have shown that by the age of five, virtually all children have been exposed to the virus and reinfections appear to be common. Human metapneumovirus may cause mild respiratory tract infection. However, small children, elderly and immunocompromised individuals are at risk of severe disease and hospitalization.
hMPV related resources and publications