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ImmuneActivation (permalink) (comment) 17 Feb 2007
- Rate of HIV evolution predicts onset of AIDS
- 1985: Li and Wu's molecular clock paper:
  - substitution rate varies in mammals
    - some (chimps, humans) evolve slow
    - some (mice, rats) evolve faster
  - this causes distortions
    - away from the "molecular clock"
    - away from "ultrametric" trees
    - somewhat asymmetric behavior.
  - A simple explanation fits the data:
    - fast evolutionary rate, short generation time
    - fast evolutionary rate, fast replication.
- 2003: Wen-Hsiung Li gets Balzan prize
- 2007: Rambaut et al on HIV evolution:
  - substitution rate correlates with disease progression
    - fast evolutionary rate, fast HIV replication.
  - Immune activation is known to cause disease.
    - So it also accelerates replication
  - Most primates don't get AIDS from SIV's.
    - Do lentivirii flee immunogenic phenotypes?
- More HIV: evo in silico from McCammon @HHMI (2006)
- Synthetic exploration of fitness landscapes @Nature (2007)

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