Human Coronavirus OC43

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Table of Contents:

Human Coronavirus OC43

Introduction

A member of Coronaviridae.
Host: Human
NCBI Reference sequence: NC_005147.1
Genome length: 31,357 nt
ssRNA, (+) strand, linear
Non-segmented
10 genes
GC content: 36.9%

A brief history

Human coronavirus OC43, or HCoV-OC43, was first isolated in 1967 from volunteers at the Common Cold Unit in Salisbury, United Kingdom. Together with HCoV-229E, HCoV-OC43 causes 10-30% of all common colds.

Taxonomy

Group Group IV (Wikipedia:Positive-sense_ssRNA_virus#Group_IV_-_positive-sense_ssRNA_viruses)
Order Nidovirales (Wikipedia:Nidovirales)
Family Coronaviridae (Wikipedia:Coronaviridae)
Genera Coronavirus (Wikipedia:Coronavirus)

Coronaviruses

Coronaviruses are enveloped, (+)ssRNA viruses which infect animals. Commonly they infect the upper respiratory or GI tract. They are responsible for diseases including the common cold and SARS. The 5'-end of the genome has a methylated cap and the 3'-end has a poly (A) tract, mimicking host mRNA. Host ribosomes readily attach to the viral genome and initiate translation.

References

ICTVdB - The Universal Virus Database, version 4
Vijgen L, Keyaerts E, Moes E, Thoelen I, Wollants E, Lemey P, Vandamme AM, Van Ranst M. Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. J Virol. 2005 Feb;79(3):1595-604.
Larson HE, Reed SE, Tyrrell DA. Isolation of rhinoviruses and coronaviruses from 38 colds in adults. J Med Virol. 1980;5(3):221-9.

-- ArthurYu - 11 Dec 2009

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