Human Coronavirus OC43
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OMGBrowse site for HCoV-OC43
Table of Contents:
- A member of Coronaviridae.
- Host: Human
- NCBI Reference sequence: NC_005147.1
- Genome length: 31,357 nt
- ssRNA, (+) strand, linear
- 10 genes
- GC content: 36.9%
A brief history
Human coronavirus OC43, or HCoV-OC43, was first isolated in 1967 from volunteers at the Common Cold Unit in Salisbury, United Kingdom. Together with HCoV-229E, HCoV-OC43 causes 10-30% of all common colds.
Group Group IV
Coronaviruses are enveloped, (+)ssRNA viruses which infect animals. Commonly they infect the upper respiratory or GI tract. They are responsible for diseases including the common cold and SARS
. The 5'-end of the genome has a methylated cap and the 3'-end has a poly (A) tract, mimicking host mRNA. Host ribosomes readily attach to the viral genome and initiate translation.
- ICTVdB - The Universal Virus Database, version 4
- Vijgen L, Keyaerts E, Moes E, Thoelen I, Wollants E, Lemey P, Vandamme AM, Van Ranst M. Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. J Virol. 2005 Feb;79(3):1595-604.
- Larson HE, Reed SE, Tyrrell DA. Isolation of rhinoviruses and coronaviruses from 38 colds in adults. J Med Virol. 1980;5(3):221-9.
- 11 Dec 2009
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