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r2068 - 2013-06-20 - 13:00

Yeah that's what I'm talinkg about baby nice work! Mar 2012 8757 2 0 1908 WebRss 1107 WebHome 492 WebSearch 480 WebCritic 192 WebStatistics ...

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IanHolmes

r7 - 2005-11-25 - 15:00

WebCritic on 25 Nov 2005 Happy thanksgiving... enjoy your turkey Quoted: Randy Rettberg, Drew Endy, Gos Micklem, Melissa Li Photographed ...

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JasonStajich

r2 - 2005-06-08 - 18:42

JasonStajich on 08 Jun 2005 Test2

RaphKoster

IanHolmes

r18 - 2007-03-10 - 05:02

UPDATE: Raph's comment below indicates that I did, in fact, misinterpret his reaction to "Bioengineering". I now feel like a complete tool... ah well... I do enjoy ...

ParanoiaRPG

IanHolmes

r22 - 2007-06-04 - 22:08

The computer is your friend I was sad enough to be into several RPG's as a teen geek in the 80's. Maelstrom, D D, Traveller... my favorite, however, was the classic ...

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IanHolmes

r5 - 2006-01-08 - 05:30

JasonStajich on June 24 2005 @ 6:51am BOSCBlog http://www.affymetrix.com/support/developer/tools/download igb.affx GregHelt 's talk at BOSC, about ...

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r2068 - 2013-06-20 - 13:00

Yeah that's what I'm talinkg about baby nice work! Mar 2012 8757 2 0 1908 WebRss 1107 WebHome 492 WebSearch 480 WebCritic 192 WebStatistics ...

AncestralSequenceReconstruction

IanHolmes

r5 - 2008-01-23 - 20:12

ISBN:0199299188 University Press Amazon.com http://mbe.oxfordjournals.org/cgi/content/full/21/10/1871

CyberpunkRealism

IanHolmes

r15 - 2007-10-10 - 10:50

coined the word " http://en.wikipedia.org/wiki/Transrealism Transrealism" for the process of creating sci fi by taking vignettes from your own autobiography and ...

ParanoiaRPG

IanHolmes

r22 - 2007-06-04 - 22:08

The computer is your friend I was sad enough to be into several RPG's as a teen geek in the 80's. Maelstrom, D D, Traveller... my favorite, however, was the classic ...

NotesAndComments

IanHolmes

r471 - 2007-05-05 - 16:44

Notes and Comments and evolution of human microRNAs from transposable elements Spells DNA in your face http://www.genome.org/cgi/content/abstract ...

RaphKoster

IanHolmes

r18 - 2007-03-10 - 05:02

UPDATE: Raph's comment below indicates that I did, in fact, misinterpret his reaction to "Bioengineering". I now feel like a complete tool... ah well... I do enjoy ...

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Web Critic

ImmuneActivation (permalink) (comment) 17 Feb 2007 %STARTSUMMARY%

Rate of HIV evolution predicts onset of AIDS

1985: Li and Wu's molecular clock paper:

substitution rate varies in mammals

some (chimps, humans) evolve slow

some (mice, rats) evolve faster

this causes distortions

away from the "molecular clock"

away from "ultrametric" trees

somewhat asymmetric behavior.

A simple explanation fits the data:

fast evolutionary rate, short generation time

fast evolutionary rate, fast replication.

2003: Wen-Hsiung Li gets Balzan prize

2007: Rambaut et al on HIV evolution:

substitution rate correlates with disease progression

fast evolutionary rate, fast HIV replication.

Immune activation is known to cause disease.

So it also accelerates replication

Most primates don't get AIDS from SIV's.

Do lentivirii flee immunogenic phenotypes?

More HIV: evo in silico from McCammon @HHMI (2006)

Synthetic exploration of fitness landscapes @Nature (2007)

%STOPSUMMARY%
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